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Literature summary for 6.5.1.1 extracted from

  • Gao, Y.; Katyal, S.; Lee, Y.; Zhao, J.; Rehg, J.; Russell, H.; McKinnon, P.
    DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair (2011), Nature, 471, 240-246.
    View publication on PubMedView publication on EuropePMC

General Stability

General Stability Organism
Lig3 stability depends upon its nuclear binding partner Xrcc1 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Mus musculus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
110000
-
x * 110000, SDS-PAGE Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain cortex
-
Mus musculus
-
cerebellum
-
Mus musculus
-

Subunits

Subunits Comment Organism
? x * 110000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
DNA ligase III
-
Mus musculus
Lig3
-
Mus musculus
ligase III
-
Mus musculus

General Information

General Information Comment Organism
malfunction inactivation of Lig3 in the mouse nervous system results in mitochondrial DNA loss leading to profound mitochondrial dysfunction, disruption of cellular homeostasis and incapacitating ataxia. Lig3 inactivation causes cardiac failure associated with defective mitochondrial function Mus musculus
physiological function DNA ligase III 3 is a key ligase during base excision repair. DNA ligase III is critical for mitochondrial DNA integrity but not Xrcc1-mediated nuclear DNA repair Mus musculus