General Stability | Organism |
---|---|
Lig3 stability depends upon its nuclear binding partner Xrcc1 | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Mus musculus | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
110000 | - |
x * 110000, SDS-PAGE | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain cortex | - |
Mus musculus | - |
cerebellum | - |
Mus musculus | - |
Subunits | Comment | Organism |
---|---|---|
? | x * 110000, SDS-PAGE | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
DNA ligase III | - |
Mus musculus |
Lig3 | - |
Mus musculus |
ligase III | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | inactivation of Lig3 in the mouse nervous system results in mitochondrial DNA loss leading to profound mitochondrial dysfunction, disruption of cellular homeostasis and incapacitating ataxia. Lig3 inactivation causes cardiac failure associated with defective mitochondrial function | Mus musculus |
physiological function | DNA ligase III 3 is a key ligase during base excision repair. DNA ligase III is critical for mitochondrial DNA integrity but not Xrcc1-mediated nuclear DNA repair | Mus musculus |