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Literature summary for 6.5.1.1 extracted from

  • Soza, S.; Leva, V.; Vago, R.; Ferrari, G.; Mazzini, G.; Biamonti, G.; Montecucco, A.
    DNA ligase I deficiency leads to replication-dependent DNA damage and impacts cell morphology without blocking cell cycle progression (2009), Mol. Cell. Biol., 29, 2032-2041.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m Homo sapiens
-
AMP + diphosphate + (deoxyribonucleotide)n+m
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
46BR.1G1 cell the cell line is characterized by drastically reduced replicative DNA ligase I activity Homo sapiens
-
MRC-5V1 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
-
Homo sapiens AMP + diphosphate + (deoxyribonucleotide)n+m
-
?

Synonyms

Synonyms Comment Organism
ATP-dependent DNA ligase I
-
Homo sapiens
LigI
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens

General Information

General Information Comment Organism
malfunction DNA ligase I deficiency leads to replication-dependent DNA damage and impacts cell morphology without blocking cell cycle progression. LigI deficiency affects the maturation of nascent DNA and increases the frequency of gammaH2AX foci throughout the cell cycle. LigI deficiency leads to chronic activation of the ataxia telangiectasia mutated-mediated DNA damage checkpoint Homo sapiens