Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2-hydroxyphenyl)(4-hydroxyphenyl)methanone | 50.7% inhibition at 0.1 mM | Homo sapiens | |
2,3-dioxo-2,3-dihydro-1H-indole-7-carboxylic acid | 59.3% inhibition at 0.1 mM | Homo sapiens | |
2-[(3,5-dibromo-4-methylphenyl)amino]-N'-[(1Z)-(2-hydroxy-5-nitrophenyl)methylidene]acetohydrazide | 78.3% inhibition at 0.1 mM | Homo sapiens | |
3-amino-2-[[(1E)-phenylmethylidene]amino]-5-sulfanylphenol | 68.8% inhibition at 0.1 mM | Homo sapiens | |
3-[(4-bromophenyl)sulfonyl]-N-[2-(4-sulfamoylphenyl)ethyl]propanamide | 53.4% inhibition at 0.1 mM | Homo sapiens | |
4-([[(4-carboxy-5-methylfuran-2-yl)methyl]sulfanyl]methyl)-5-methylfuran-2-carboxylic acid | 91% inhibition at 0.1 mM | Homo sapiens | |
4-chloro-5-[(2Z)-2-[(4-hydroxy-3-nitrophenyl)methylidene]hydrazino]pyridazin-3(2H)-one | 59.8% inhibition at 0.1 mM | Homo sapiens | |
5-(methylsulfanyl)thiophene-2-carboxylic acid | 60.5% inhibition at 0.1 mM | Homo sapiens | |
7-(4-methoxyphenyl)pteridine-2,4-diol | 52.5% inhibition at 0.1 mM | Homo sapiens | |
[(7-chloro-4-nitro-2,1,3-benzoxadiazol-5-yl)sulfanyl]acetic acid | 60.6% inhibition at 0.1 mM | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P18858 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HCT-116 cell | - |
Homo sapiens | - |
MCF-10A cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m | - |
Homo sapiens | AMP + diphosphate + (deoxyribonucleotide)m+n | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DNA ligase | - |
Homo sapiens |
LigI | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0006 | - |
- |
Homo sapiens | 4-([[(4-carboxy-5-methylfuran-2-yl)methyl]sulfanyl]methyl)-5-methylfuran-2-carboxylic acid | |
0.004 | - |
- |
Homo sapiens | 2,3-dioxo-2,3-dihydro-1H-indole-7-carboxylic acid | |
0.01 | - |
- |
Homo sapiens | 5-(methylsulfanyl)thiophene-2-carboxylic acid | |
0.013 | - |
- |
Homo sapiens | [(7-chloro-4-nitro-2,1,3-benzoxadiazol-5-yl)sulfanyl]acetic acid | |
0.018 | - |
- |
Homo sapiens | 3-[(4-bromophenyl)sulfonyl]-N-[2-(4-sulfamoylphenyl)ethyl]propanamide | |
0.025 | - |
- |
Homo sapiens | 7-(4-methoxyphenyl)pteridine-2,4-diol | |
0.025 | - |
- |
Homo sapiens | (2-hydroxyphenyl)(4-hydroxyphenyl)methanone |