Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.5.1.1 extracted from

  • Mortusewicz, O.; Rothbauer, U.; Cardoso, M.C.; Leonhardt, H.
    Differential recruitment of DNA ligase I and III to DNA repair sites (2006), Nucleic Acids Res., 34, 3523-3532.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.5.1.1

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m Homo sapiens ligation of DNA is the ultimate step in DNA repair to restore genome integrity. Ligase I and III accumulate at DNA repair sites. DNA Ligase III accumulates at microirradiated sites before DNA ligase. Recruitment of DNA ligase I to sites of DNA damage depends on its interaction with PCNA AMP + diphosphate + (deoxyribonucleotide)n+m
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell introduction of DNA lesions in human cells by laser microirradiation. DNA ligase I and III accumulate at DNA repair sites. DNA Ligase III accumulates at microirradiated sites before DNA ligase I. Recruitment of DNA ligase I to sites of DNA damage depends on its interaction with PCNA Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m ligation of DNA is the ultimate step in DNA repair to restore genome integrity. Ligase I and III accumulate at DNA repair sites. DNA Ligase III accumulates at microirradiated sites before DNA ligase. Recruitment of DNA ligase I to sites of DNA damage depends on its interaction with PCNA Homo sapiens AMP + diphosphate + (deoxyribonucleotide)n+m
-
 ?

Synonyms

Synonyms Comment Organism
DNA ligase I
-
 Homo sapiens