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Literature summary for 6.5.1.1 extracted from

  • Zhao, A.; Gray, F.C.; MacNeill, S.A.
    ATP- and NAD+-dependent DNA ligases share an essential function in the halophilic archaeon Haloferax volcanii (2006), Mol. Microbiol., 59, 743-752.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m Haloferax volcanii ATP-dependent DNA ligase LigA is non-essential for cell viability. Haloferax volcanii also encodes the NAD+-dependent DNA ligase LigN. As with LigA, LigN is also non-essential for cell viability. Simultaneous inactivation of both proteins is lethal, however, indicating that they share an essential function AMP + diphosphate + (deoxyribonucleotide)n+m
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Organism

Organism UniProt Comment Textmining
Haloferax volcanii
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m ATP-dependent DNA ligase LigA is non-essential for cell viability. Haloferax volcanii also encodes the NAD+-dependent DNA ligase LigN. As with LigA, LigN is also non-essential for cell viability. Simultaneous inactivation of both proteins is lethal, however, indicating that they share an essential function Haloferax volcanii AMP + diphosphate + (deoxyribonucleotide)n+m
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Synonyms

Synonyms Comment Organism
ATP-dependent DNA ligase
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Haloferax volcanii
LigA
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Haloferax volcanii