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Literature summary for 6.5.1.1 extracted from

  • Mackey, Z.B.; Niedergang, C.; Murcia, J.M.D.; Leppard, J.; Au, K.; Chen, J.; De Murcia, G.; Tomkinson, A.E.
    DNA ligase III is recruited to DNA strand breaks by a zinc finger motif homologous to that of poly(ADP-ribose) polymerase. Identification of two functionally distinct DNA binding regions within DNA ligase III (1999), J. Biol. Chem., 274, 21679-21687.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Sf9 insect cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
F717L amino acid substitution within the conserved peptide of DNA ligase IIIbeta, does not complement Escherichia coli lig mutant Homo sapiens
G712A amino acid substitution within the conserved peptide of DNA ligase IIIbeta, complements Escherichia coli lig mutant Homo sapiens
K724E amino acid substitution within the conserved peptide of DNA ligase IIIbeta, does not complement Escherichia coli lig mutant Homo sapiens
K727G amino acid substitution within the conserved peptide of DNA ligase IIIbeta, does not complement Escherichia coli lig mutant Homo sapiens
K727R amino acid substitution within the conserved peptide of DNA ligase IIIbeta, does not complement Escherichia coli lig mutant Homo sapiens
P718A amino acid substitution within the conserved peptide of DNA ligase IIIbeta, complements Escherichia coli lig mutant Homo sapiens
P718T amino acid substitution within the conserved peptide of DNA ligase IIIbeta, complements Escherichia coli lig mutant Homo sapiens
p719G amino acid substitution within the conserved peptide of DNA ligase IIIbeta, does not complement Escherichia coli lig mutant, thermolabile mutant Homo sapiens
R716G amino acid substitution within the conserved peptide of DNA ligase IIIbeta, does not complement Escherichia coli lig mutant Homo sapiens
R722Q amino acid substitution within the conserved peptide of DNA ligase IIIbeta, complements Escherichia coli lig mutant Homo sapiens
R722V amino acid substitution within the conserved peptide of DNA ligase IIIbeta, complements Escherichia coli lig mutant Homo sapiens
R724G amino acid substitution within the conserved peptide of DNA ligase IIIbeta, does not complement Escherichia coli lig mutant Homo sapiens
S714I amino acid substitution within the conserved peptide of DNA ligase IIIbeta, does not complement Escherichia coli lig mutant Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m Homo sapiens
-
AMP + diphosphate + (deoxyribonucleotide)m+n
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant DNA ligase III Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
-
Homo sapiens AMP + diphosphate + (deoxyribonucleotide)m+n
-
?

Synonyms

Synonyms Comment Organism
DNA ligase III
-
Homo sapiens