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Literature summary for 6.5.1.1 extracted from

  • Sun, D.; Urrabaz, R.; Kelly, S.; Nguyen, M.; Weitman, S.
    Enhancement of DNA ligase I level by gemcitabine in human cancer cells (2002), Clin. Cancer Res., 8, 1189-1195.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m Homo sapiens essential enzyme for completing DNA replication and DNA repair by ligating Okazaki fragments and by joining single-strand breaks formed either by DNA-damaging agents or indirectly by DNA repair enzymes, respectively AMP + diphosphate + (deoxyribonucleotide)m+n
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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2-3fold increase in DNA ligase I protein levels after 1 day exposure of MiaPaCa cells to 0.000015-0.00024 mM 2',2'-difluoro-2'-deoxycytidine
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Source Tissue

Source Tissue Comment Organism Textmining
neuroblastoma cell cell lines NGP and SK-N-Be Homo sapiens
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pancreatic cancer cell line MiaPaCa cell line Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
-
Homo sapiens AMP + diphosphate + (deoxyribonucleotide)m+n
-
?
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m essential enzyme for completing DNA replication and DNA repair by ligating Okazaki fragments and by joining single-strand breaks formed either by DNA-damaging agents or indirectly by DNA repair enzymes, respectively Homo sapiens AMP + diphosphate + (deoxyribonucleotide)m+n
-
?

Synonyms

Synonyms Comment Organism
DNA ligase I
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Homo sapiens