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Literature summary for 6.4.1.3 extracted from

  • Collard, R.; Majtan, T.; Park, I.; Kraus, J.P.
    Import of TAT-conjugated propionyl-CoA carboxylase using models of propionic acidemia (2018), Mol. Cell. Biol., 38, e00491 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.4.1.3

Application

Application Comment Organism
medicine treatment of propionic acidemia by import of a biologically active, fully assembled propionyl-CoA carboxylase dodecamer, posttranslationally chemically conjugated with the HIV TAT peptide. TAT-propionyl-CoA carboxylase is transferred into isolated mitochondria, as well as into mitochondria of patient fibroblasts . A single-dose intraperitoneal injection into propionyl-CoA carboxylase-deficient mice decreases the propionylcarnitine/acetylcarnitine (C3/C2) ratio toward the normal level Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
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Organism

Organism UniProt Comment Textmining
Homo sapiens P05166 and P05165 P05165 i.e. subunit PccA, P05166 i.e. subunit PccB
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Synonyms

Synonyms Comment Organism
PccA
-
 Homo sapiens
PccB
-
 Homo sapiens