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Literature summary for 6.4.1.3 extracted from

  • Jung, W.S.; Yoo, Y.J.; Park, J.W.; Park, S.R.; Han, A.R.; Ban, Y.H.; Kim, E.J.; Kim, E.; Yoon, Y.J.
    A combined approach of classical mutagenesis and rational metabolic engineering improves rapamycin biosynthesis and provides insights into methylmalonyl-CoA precursor supply pathway in Streptomyces hygroscopicus ATCC 29253 (2011), Appl. Microbiol. Biotechnol., 91, 1389-1397.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
introduced into Streptomyces hygroscopicus UV2-2 strain by conjugation from Escherichia coli ET12567/pUZ8002 Streptomyces hygroscopicus

Organism

Organism UniProt Comment Textmining
Streptomyces hygroscopicus
-
-
-
Streptomyces hygroscopicus ATCC 29253
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
propionyl-CoA + CO2
-
Streptomyces hygroscopicus (2S)-methylmalonyl-CoA
-
?
propionyl-CoA + CO2
-
Streptomyces hygroscopicus ATCC 29253 (2S)-methylmalonyl-CoA
-
?

Synonyms

Synonyms Comment Organism
PCC
-
Streptomyces hygroscopicus
Propionyl-CoA carboxylase
-
Streptomyces hygroscopicus

General Information

General Information Comment Organism
physiological function the PCC pathway is the dominant route for the supply of methylmalonyl-CoA for rapamycin production in Streptomyces hygroscopicus UV2-2 strain Streptomyces hygroscopicus