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Literature summary for 6.4.1.2 extracted from

  • Monteuuis, G.; Suomi, F.; Keraetaer, J.M.; Masud, A.J.; Kastaniotis, A.J.
    A conserved mammalian mitochondrial isoform of acetyl-CoA carboxylase ACC1 provides the malonyl-CoA essential for mitochondrial biogenesis in tandem with ACSF3 (2017), Biochem. J., 474, 3783-3797 .
    View publication on PubMed
Search for more literature for 6.4.1.2

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-
mitochondrion
-
 Mus musculus 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13085
-
-
Mus musculus Q5SWU9
-
-

Synonyms

Synonyms Comment Organism
ACACA
-
 Homo sapiens
ACACA
-
 Mus musculus
ACC1
-
 Homo sapiens
ACC1
-
 Mus musculus

General Information

General Information Comment Organism
physiological function inactivation of the putative mitochondrial targeting sequence leads to decreased lipoylation and mitochondrial fragmentation Homo sapiens
physiological function specific knockdown of Acc1 leads to decreased lipoylation and mitochondrial fragmentation. Simultaneous knockdown of ACSF3, encoding a mitochondrial malonyl-CoA synthetase, results in almost complete ablation of protein lipoylation Mus musculus