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Literature summary for 6.4.1.2 extracted from

  • Spencer, C.M.; Schafer, X.L.; Moorman, N.J.; Munger, J.
    Human cytomegalovirus induces the activity and expression of acetyl-coenzyme A carboxylase, a fatty acid biosynthetic enzyme whose inhibition attenuates viral replication (2011), J. Virol., 85, 5814-5824.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information human cytomegalovirus infection also induces isoform ACC1's enzymatic activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
5-tetradecyloxy-2-furoic acid
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
250000
-
x * 250000, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
Homo sapiens
-
MRC-5 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetyl-CoA + HCO3-
-
Homo sapiens ADP + malonyl-CoA + phosphate
-
?

Subunits

Subunits Comment Organism
? x * 250000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
ACC1 isoform Homo sapiens
Acetyl-coenzyme A carboxylase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens human cytomegalovirus infection activates ACC1 expression about 3fold 72 h post infection, increasing the abundance of both ACC1 mRNA and protein. Viral gene expression but not viral DANN replication is necessary for human cytomegalovirus-mediated induction of ACC1 levels up

General Information

General Information Comment Organism
malfunction inhibition of ACC1 through either RNA interference or inhibitor treatment (0.01 mg/ml 5-tetradecyloxy-2-furoic acid) attenuates human cytomegalovirus replication Homo sapiens
metabolism ACC1 is the rate-limiting enzyme of fatty acid biosynthesis Homo sapiens