Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | human cytomegalovirus infection also induces isoform ACC1's enzymatic activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-tetradecyloxy-2-furoic acid | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
250000 | - |
x * 250000, SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Homo sapiens | - |
MRC-5 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + acetyl-CoA + HCO3- | - |
Homo sapiens | ADP + malonyl-CoA + phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 250000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
ACC1 | isoform | Homo sapiens |
Acetyl-coenzyme A carboxylase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | human cytomegalovirus infection activates ACC1 expression about 3fold 72 h post infection, increasing the abundance of both ACC1 mRNA and protein. Viral gene expression but not viral DANN replication is necessary for human cytomegalovirus-mediated induction of ACC1 levels | up |
General Information | Comment | Organism |
---|---|---|
malfunction | inhibition of ACC1 through either RNA interference or inhibitor treatment (0.01 mg/ml 5-tetradecyloxy-2-furoic acid) attenuates human cytomegalovirus replication | Homo sapiens |
metabolism | ACC1 is the rate-limiting enzyme of fatty acid biosynthesis | Homo sapiens |