Activating Compound | Comment | Organism | Structure |
---|---|---|---|
citrate | an intermediate metabolite, activates hypothalamic ACC and is involved in the control of energy mobilization | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + acetyl-CoA + HCO3- | Rattus norvegicus | intracellular citrate controls ACC activity and malonyl-CoA levels, and diminishes food intake, physiological regulation system involving citrate, overview | ADP + phosphate + malonyl-CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male Wistar Hannover rats | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | ACC is inactivated by phosphorylation through AMP-activated protein kinase, AMPK, citrate treatment inhibits 75% of control hypothalamic AMPK phosphorylation during fasting, overview | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hypothalamus | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + acetyl-CoA + HCO3- | - |
Rattus norvegicus | ADP + phosphate + malonyl-CoA | - |
? | |
ATP + acetyl-CoA + HCO3- | intracellular citrate controls ACC activity and malonyl-CoA levels, and diminishes food intake, physiological regulation system involving citrate, overview | Rattus norvegicus | ADP + phosphate + malonyl-CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ACC | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |