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Literature summary for 6.4.1.2 extracted from

  • Ray, H.; Suau, F.; Vincent, A.; Dalla Venezia, N.
    Cell cycle regulation of the BRCA1/acetyl-CoA-carboxylase complex (2009), Biochem. Biophys. Res. Commun., 378, 615-619.
    View publication on PubMed
Search for more literature for 6.4.1.2

Cloned(Commentary)

Cloned (Comment) Organism
expression of Myc-tagged wild-type and mutant enzymes in Bosc cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
S1263A site-directed mutagenesis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
BRCA1 protein BRCA1 reduces acetyl-CoA-carboxylase alpha, ACCA, activity through its phospho-dependent binding to ACCA, the phosphorylation of the Ser1263 of ACCA is required for this interaction Homo sapiens
additional information ACCA is not affected by roscovitine Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme interacts with the BRCA1 protein, that is involved in multiple cellular functions, BRCA1 reduces acetyl-CoA-carboxylase alpha, ACCA, activity through its phospho-dependent binding to ACCA, the phosphorylation of the Ser1263 of ACCA is required for this interaction, the interaction between BRCA1 and ACCA is regulated during cell cycle progression, increased interaction occurs when the cells progress to G2/M, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein Ser1263 of ACCA is phosphorylated in vivo, in a cell cycle-dependent manner, by the BRCA1 protein leading to reduced ACCA activity, the interaction between BRCA1 and ACCA is regulated during cell cycle progression, increased interaction occurs when the cells progress to G2/M, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme interacts with the BRCA1 protein, that is involved in multiple cellular functions, BRCA1 reduces acetyl-CoA-carboxylase alpha, ACCA, activity through its phospho-dependent binding to ACCA, the phosphorylation of the Ser1263 of ACCA is required for this interaction, the interaction between BRCA1 and ACCA is regulated during cell cycle progression, increased interaction occurs when the cells progress to G2/M, overview Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
AccA
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 Homo sapiens
acetyl-CoA-carboxylase
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 Homo sapiens