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Literature summary for 6.4.1.2 extracted from

  • Cheng, D.; Chu, C.H.; Chen, L.; Feder, J.N.; Mintier, G.A.; Wu, Y.; Cook, J.W.; Harpel, M.R.; Locke, G.A.; An, Y.; Tamura, J.K.
    Expression, purification, and characterization of human and rat acetyl coenzyme A carboxylase (ACC) isozymes (2007), Protein Expr. Purif., 51, 11-21.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
citrate barely detectable activity without citrate Rattus norvegicus
citrate barely detectable activity without citrate Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Sf9 cells Rattus norvegicus
expressed in Sf9 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
malonyl-CoA
-
Homo sapiens
palmitoyl-CoA
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.034
-
acetyl-CoA at 37°C Homo sapiens
0.037
-
acetyl-CoA at 37°C Rattus norvegicus
0.058
-
acetyl-CoA at 37°C Homo sapiens
0.12
-
ATP at 37°C Homo sapiens
0.147
-
ATP at 37°C Rattus norvegicus
0.147
-
ATP at 37°C Homo sapiens
3
-
HCO3- at 37°C Homo sapiens
5.1
-
HCO3- at 37°C Rattus norvegicus
12.8
-
HCO3- at 37°C Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
250000
-
gel filtration Rattus norvegicus
250000
-
gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O00763
-
-
Homo sapiens Q13085
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
c-Myc-5 monoclonal IgG column chromatography and Sephacryl S-300 gel filtration Rattus norvegicus
c-Myc-5 monoclonal IgG column chromatography and Sephacryl S-300 gel filtration Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
muscle
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetyl-CoA + HCO3-
-
Rattus norvegicus ADP + phosphate + malonyl-CoA
-
?
ATP + acetyl-CoA + HCO3-
-
Homo sapiens ADP + phosphate + malonyl-CoA
-
?

Synonyms

Synonyms Comment Organism
ACC1
-
Homo sapiens
ACC2
-
Rattus norvegicus
ACC2
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
10.1
-
acetyl-CoA at 37°C Homo sapiens
11.6
-
acetyl-CoA at 37°C Rattus norvegicus
11.8
-
acetyl-CoA at 37°C Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Rattus norvegicus
ATP
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0008
-
palmitoyl-CoA
-
Homo sapiens
0.009
-
malonyl-CoA
-
Homo sapiens