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Literature summary for 6.4.1.2 extracted from

  • Tong, L.; Harwood, H.J.
    Acetyl-coenzyme A carboxylases: versatile targets for drug discovery (2006), J. Cell. Biochem., 99, 1476-1488.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.4.1.2

Inhibitors

Inhibitors Comment Organism Structure
(+)-p-[1-(p-tert-butylphenyl)-2-oxo-4-pyrrolidinyl]methoxybenzoic acid
-
 Homo sapiens
5-(tetradecyloxy)-2-furancarboxylic acid
-
 Homo sapiens
8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid
-
 Homo sapiens
beta,beta,beta',beta'-tetramethylhexadecanoic acid
-
 Homo sapiens
CP-640186
-
 Homo sapiens
Haloxyfop
-
 Homo sapiens
pyridoxal phosphate weak inhibitor; weak inhibitor Homo sapiens
Sethoxydim
-
 Homo sapiens
soraphen A
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-
membrane
-
 Homo sapiens 16020
-
mitochondrion
-
 Homo sapiens 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
265000
-
-
 Homo sapiens
280000
-
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O00763
-
-
Homo sapiens Q13085
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue
-
 Homo sapiens
-
heart
-
 Homo sapiens
-
liver
-
 Homo sapiens
-
skeletal muscle
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetyl-CoA + HCO3-
-
 Homo sapiens ADP + phosphate + malonyl-CoA
-
 ?

Synonyms

Synonyms Comment Organism
ACC1
-
 Homo sapiens
ACC2
-
 Homo sapiens
Acetyl-coenzyme A carboxylase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00006
-
-
 Homo sapiens CP-640186