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Literature summary for 6.4.1.2 extracted from

  • Clark, R.F.; Zhang, T.; Xin, Z.; Liu, G.; Wang, Y.; Hansen, T.M.; Wang, X.; Wang, R.; Zhang, X.; Frevert, E.U.; Camp, H.S.; Beutel, B.A.; Sham, H.L.; Gu, Y.G.
    Structure-activity relationships for a novel series of thiazolyl phenyl ether derivatives exhibiting potent and selective acetyl-CoA carboxylase 2 inhibitory activity (2006), Bioorg. Med. Chem. Lett., 16, 6078-6081.
    View publication on PubMed
Search for more literature for 6.4.1.2

Inhibitors

Inhibitors Comment Organism Structure
CP-640186
-
 Homo sapiens
methyl [4-([5-[3-(acetylamino)but-1-yn-1-yl]-1,3-thiazol-2-yl]oxy)phenoxy]acetate
-
 Homo sapiens
N-(1-methyl-3-[2-[2-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
 Homo sapiens
N-(1-methyl-3-[2-[3-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
 Homo sapiens
N-(1-methyl-3-[2-[3-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
 Homo sapiens
N-(1-methyl-3-[2-[3-(tetrahydrofuran-3-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
 Homo sapiens
N-(1-methyl-3-[2-[3-(trifluoromethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
 Homo sapiens
N-(1-methyl-3-[2-[3-([[(1-methylethyl)amino]oxy]methyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
 Homo sapiens
N-(1-methyl-3-[2-[4-(1,3-thiazolidin-2-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
 Homo sapiens
N-(1-methyl-3-[2-[4-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide potent and selective inhibitor Homo sapiens
N-(1-methyl-3-[2-[4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
 Homo sapiens
N-(1-methyl-3-[2-[4-(2-methylpropyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
 Homo sapiens
N-(1-methyl-3-[2-[4-(pyridin-2-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
 Homo sapiens
N-(1-methyl-3-[2-[4-(tetrahydrofuran-3-ylmethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
 Homo sapiens
N-(1-methyl-3-[2-[4-(tetrahydrofuran-3-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
 Homo sapiens
N-(1-methyl-3-[2-[4-([[(1-methylethyl)amino]oxy]methyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
 Homo sapiens
N-(3-[2-[3-(cyclohexyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
 Homo sapiens
N-(3-[2-[4-(cyclohexylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
 Homo sapiens
N-(3-[2-[4-(cyclohexyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
 Homo sapiens
N-(3-[2-[4-(cyclopentylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
 Homo sapiens
N-(3-[2-[4-(cyclopentyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
 Homo sapiens
N-[1-methyl-3-(2-phenoxy-1,3-thiazol-5-yl)prop-2-yn-1-yl]acetamide
-
 Homo sapiens
N-[1-methyl-3-(2-[4-[(1-methylethyl)amino]phenoxy]-1,3-thiazol-5-yl)prop-2-yn-1-yl]acetamide
-
 Homo sapiens
N-[1-methyl-3-(2-[4-[(1-methylethyl)sulfanyl]phenoxy]-1,3-thiazol-5-yl)prop-2-yn-1-yl]acetamide
-
 Homo sapiens
N-[1-methyl-3-[2-(3-phenoxyphenoxy)-1,3-thiazol-5-yl]prop-2-yn-1-yl]acetamide
-
 Homo sapiens
N-[1-methyl-3-[2-(4-phenoxyphenoxy)-1,3-thiazol-5-yl]prop-2-yn-1-yl]acetamide
-
 Homo sapiens
N-[3-(2-[4-[(ethylperoxy)sulfanyl]phenoxy]-1,3-thiazol-5-yl)-1-methylprop-2-yn-1-yl]acetamide
-
 Homo sapiens
N-[3-(2-[4-[3-(dimethylamino)propoxy]phenoxy]-1,3-thiazol-5-yl)-1-methylprop-2-yn-1-yl]acetamide
-
 Homo sapiens
N-[3-[2-(2-ethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
 Homo sapiens
N-[3-[2-(2-methoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
 Homo sapiens
N-[3-[2-(3,4-dimethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
 Homo sapiens
N-[3-[2-(3,5-dimethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
 Homo sapiens
N-[3-[2-(3-methoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
 Homo sapiens
N-[3-[2-(4-ethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
 Homo sapiens
N-[3-[2-(4-hydroxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
 Homo sapiens
N-[3-[2-(4-methoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
 Homo sapiens
N-[3-[2-(4-[[(ethylamino)oxy]methoxy]phenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
 Homo sapiens
[4-([5-[3-(acetylamino)but-1-yn-1-yl]-1,3-thiazol-2-yl]oxy)phenoxy]acetic acid
-
 Homo sapiens
[4-([5-[3-(acetylamino)but-1-yn-1-yl]-1,3-thiazol-2-yl]oxy)phenoxy]acetyl methylcarbamate
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetyl-CoA + HCO3-
-
 Homo sapiens ADP + phosphate + malonyl-CoA
-
 ?

Synonyms

Synonyms Comment Organism
ACC2
-
 Homo sapiens
acetyl-CoA carboxylase 2
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000044
-
 isozyme ACC2 Homo sapiens N-(1-methyl-3-[2-[4-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
0.000005
-
 isozyme ACC2 Homo sapiens N-(3-[2-[4-(cyclopentylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
0.00001
-
 isozyme ACC2 Homo sapiens N-(1-methyl-3-[2-[4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
0.000013
-
 isozyme ACC2 Homo sapiens N-(1-methyl-3-[2-[3-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
0.000013
-
 isozyme ACC2 Homo sapiens N-(3-[2-[4-(cyclopentyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
0.000014
-
 isozyme ACC2 Homo sapiens N-(1-methyl-3-[2-[3-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
0.000016
-
 isozyme ACC2 Homo sapiens N-(3-[2-[4-(cyclohexyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
0.000026
-
 isozyme ACC2 Homo sapiens N-(3-[2-[3-(cyclohexyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
0.000027
-
 isozyme ACC2 Homo sapiens N-(3-[2-[4-(cyclohexylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
0.000037
-
 isozyme ACC2 Homo sapiens N-[3-[2-(4-ethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
0.000057
-
 isozyme ACC2 Homo sapiens N-(1-methyl-3-[2-[4-(pyridin-2-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
0.000067
-
 isozyme ACC2 Homo sapiens N-(1-methyl-3-[2-[4-(tetrahydrofuran-3-ylmethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
0.000076
-
 isozyme ACC2 Homo sapiens N-[1-methyl-3-[2-(3-phenoxyphenoxy)-1,3-thiazol-5-yl]prop-2-yn-1-yl]acetamide
0.00011
-
 isozyme ACC2 Homo sapiens N-[1-methyl-3-[2-(4-phenoxyphenoxy)-1,3-thiazol-5-yl]prop-2-yn-1-yl]acetamide
0.00013
-
 isozyme ACC2 Homo sapiens N-(1-methyl-3-[2-[3-(trifluoromethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
0.00015
-
 isozyme ACC2 Homo sapiens N-[1-methyl-3-(2-[4-[(1-methylethyl)amino]phenoxy]-1,3-thiazol-5-yl)prop-2-yn-1-yl]acetamide
0.00019
-
 isozyme ACC2 Homo sapiens N-(1-methyl-3-[2-[4-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
0.00021
-
 isozyme ACC2 Homo sapiens N-(1-methyl-3-[2-[3-(tetrahydrofuran-3-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
0.00029
-
 isozyme ACC2 Homo sapiens N-(1-methyl-3-[2-[4-(1,3-thiazolidin-2-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
0.00034
-
 isozyme ACC2 Homo sapiens N-[3-[2-(4-[[(ethylamino)oxy]methoxy]phenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
0.00035
-
 isozyme ACC2 Homo sapiens N-(1-methyl-3-[2-[4-([[(1-methylethyl)amino]oxy]methyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
0.00037
-
 isozyme ACC2 Homo sapiens N-(1-methyl-3-[2-[4-(tetrahydrofuran-3-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
0.00038
-
 isozyme ACC2 Homo sapiens N-(1-methyl-3-[2-[3-([[(1-methylethyl)amino]oxy]methyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
0.00047
-
 isozyme ACC2 Homo sapiens N-[3-[2-(4-methoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
0.00055
-
 isozyme ACC2 Homo sapiens N-[1-methyl-3-(2-[4-[(1-methylethyl)sulfanyl]phenoxy]-1,3-thiazol-5-yl)prop-2-yn-1-yl]acetamide
0.00081
-
 isozyme ACC2 Homo sapiens N-(1-methyl-3-[2-[4-(2-methylpropyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
0.00085
-
 isozyme ACC2 Homo sapiens N-[3-[2-(3-methoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
0.00131
-
 isozyme ACC2 Homo sapiens N-[3-[2-(2-ethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
0.00132
-
 isozyme ACC2 Homo sapiens N-[3-[2-(2-methoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
0.00162
-
 isozyme ACC2 Homo sapiens methyl [4-([5-[3-(acetylamino)but-1-yn-1-yl]-1,3-thiazol-2-yl]oxy)phenoxy]acetate
0.0017
-
 isozyme ACC2 Homo sapiens N-[3-[2-(4-hydroxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
0.00196
-
 isozyme ACC2 Homo sapiens N-[1-methyl-3-(2-phenoxy-1,3-thiazol-5-yl)prop-2-yn-1-yl]acetamide
0.00405
-
 isozyme ACC2 Homo sapiens N-[3-(2-[4-[(ethylperoxy)sulfanyl]phenoxy]-1,3-thiazol-5-yl)-1-methylprop-2-yn-1-yl]acetamide
0.00616
-
 isozyme ACC2 Homo sapiens N-(1-methyl-3-[2-[2-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
0.01948
-
 isozyme ACC2 Homo sapiens N-(1-methyl-3-[2-[4-([[(1-methylethyl)amino]oxy]methyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
0.0265
-
 isozyme ACC2 Homo sapiens [4-([5-[3-(acetylamino)but-1-yn-1-yl]-1,3-thiazol-2-yl]oxy)phenoxy]acetyl methylcarbamate
0.03
-
 isozyme ACC2 Homo sapiens N-[3-(2-[4-[3-(dimethylamino)propoxy]phenoxy]-1,3-thiazol-5-yl)-1-methylprop-2-yn-1-yl]acetamide
0.03
-
 isozyme ACC2 Homo sapiens [4-([5-[3-(acetylamino)but-1-yn-1-yl]-1,3-thiazol-2-yl]oxy)phenoxy]acetic acid
0.03
-
 isozyme ACC2 Homo sapiens N-[3-[2-(3,4-dimethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
0.03
-
 isozyme ACC2 Homo sapiens N-[3-[2-(3,5-dimethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide