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Literature summary for 6.4.1.2 extracted from

  • Dunn, M.F.; Araiza, G.; Mora, J.
    Biochemical characterization of a Rhizobium etli monovalent cation-stimulated acyl-coenzyme A carboxylase with a high substrate specificity constant for propionyl-coenzyme A (2004), Microbiology, 150, 399-406.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetics Rhizobium etli
0.105
-
ATP pH 8.0 Rhizobium etli
0.144
-
propionyl-CoA pH 8.0 Rhizobium etli
0.392
-
acetyl-CoA pH 8.0 Rhizobium etli
0.645
-
HCO3- pH 8.0 Rhizobium etli
0.83
-
Mg2+ pH 8.0 Rhizobium etli

Metals/Ions

Metals/Ions Comment Organism Structure
Cs+ dependent on Rhizobium etli
K+ dependent on Rhizobium etli
Mg2+ absolutely required for activity Rhizobium etli
NH4+ dependent on Rhizobium etli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
45000
-
x * 74000, alpha-subunit, + x * 45000, beta-subunit, SDS-PAGE Rhizobium etli
74000
-
x * 74000, alpha-subunit, + x * 45000, beta-subunit, SDS-PAGE Rhizobium etli
620000
-
gel filtration Rhizobium etli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + acetyl-CoA + HCO3- Rhizobium etli
-
ADP + malonyl-CoA + phosphate
-
?
ATP + acetyl-CoA + HCO3- Rhizobium etli 12-53
-
ADP + malonyl-CoA + phosphate
-
?
ATP + butyryl-CoA + HCO3- + H+ Rhizobium etli
-
ADP + glutaryl-CoA + phosphate
-
?
ATP + butyryl-CoA + HCO3- + H+ Rhizobium etli 12-53
-
ADP + glutaryl-CoA + phosphate
-
?
ATP + propionyl-CoA + HCO3- + H+ Rhizobium etli participation in an anaplerotic pathway causes preference for propionyl-CoA as substrate ADP + succinyl-CoA + phosphate
-
?
additional information Rhizobium etli the enzyme is bifunctional exhibiting both acetyl-CoA carboxylase and propionyl-CoA carboxylase, EC 6.4.1.3, activities ?
-
?
additional information Rhizobium etli 12-53 the enzyme is bifunctional exhibiting both acetyl-CoA carboxylase and propionyl-CoA carboxylase, EC 6.4.1.3, activities ?
-
?

Organism

Organism UniProt Comment Textmining
Rhizobium etli
-
the activities of EC 6.4.1.2 and EC 6.4.1.3 are located on a single protein
-
Rhizobium etli 12-53
-
the activities of EC 6.4.1.2 and EC 6.4.1.3 are located on a single protein
-

Purification (Commentary)

Purification (Comment) Organism
478fold by ammonium sulfate fractionation, ion exchange chromatography, ultrafiltration, and gel filtration Rhizobium etli

Reaction

Reaction Comment Organism Reaction ID
ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA the enzyme is bifunctional exhibiting both acetyl-CoA carboxylase and propionyl-CoA carboxylase, EC 6.4.1.3, activities Rhizobium etli

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0004
-
acetyl-CoA carboxylase activity, strain CE3 Rhizobium etli
0.0005
-
acetyl-CoA carboxylase activity, strain 12-53 Rhizobium etli
0.001
-
acetyl-CoA carboxylase activity, strain CFNX218 Rhizobium etli
0.006
-
propionyl-CoA carboxylase activity, strain CE3 Rhizobium etli
0.0064
-
propionyl-CoA carboxylase activity, strain 12-53 Rhizobium etli
0.0078
-
propionyl-CoA carboxylase activity, strain CFNX218 Rhizobium etli
7.27
-
purified enzyme, substrate propionyl-CoA Rhizobium etli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetyl-CoA + HCO3-
-
Rhizobium etli ADP + malonyl-CoA + phosphate
-
?
ATP + acetyl-CoA + HCO3-
-
Rhizobium etli 12-53 ADP + malonyl-CoA + phosphate
-
?
ATP + butyryl-CoA + HCO3- + H+
-
Rhizobium etli ADP + glutaryl-CoA + phosphate
-
?
ATP + butyryl-CoA + HCO3- + H+
-
Rhizobium etli 12-53 ADP + glutaryl-CoA + phosphate
-
?
ATP + propionyl-CoA + HCO3- + H+ highly preferred substrate Rhizobium etli ADP + succinyl-CoA + phosphate
-
?
ATP + propionyl-CoA + HCO3- + H+ participation in an anaplerotic pathway causes preference for propionyl-CoA as substrate Rhizobium etli ADP + succinyl-CoA + phosphate
-
?
additional information the enzyme is bifunctional exhibiting both acetyl-CoA carboxylase and propionyl-CoA carboxylase, EC 6.4.1.3, activities Rhizobium etli ?
-
?
additional information the enzyme is bifunctional exhibiting both acetyl-CoA carboxylase and propionyl-CoA carboxylase, EC 6.4.1.3, activities Rhizobium etli 12-53 ?
-
?

Subunits

Subunits Comment Organism
oligomer x * 74000, alpha-subunit, + x * 45000, beta-subunit, SDS-PAGE Rhizobium etli

Synonyms

Synonyms Comment Organism
ACC
-
Rhizobium etli
More c.f. EC 6.4.1.3 Rhizobium etli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Rhizobium etli

Cofactor

Cofactor Comment Organism Structure
ATP dependent on Rhizobium etli
biotin dependent on Rhizobium etli