KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics | Rhizobium etli | |
0.105 | - |
ATP | pH 8.0 | Rhizobium etli | |
0.144 | - |
propionyl-CoA | pH 8.0 | Rhizobium etli | |
0.392 | - |
acetyl-CoA | pH 8.0 | Rhizobium etli | |
0.645 | - |
HCO3- | pH 8.0 | Rhizobium etli | |
0.83 | - |
Mg2+ | pH 8.0 | Rhizobium etli |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cs+ | dependent on | Rhizobium etli | |
K+ | dependent on | Rhizobium etli | |
Mg2+ | absolutely required for activity | Rhizobium etli | |
NH4+ | dependent on | Rhizobium etli |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
45000 | - |
x * 74000, alpha-subunit, + x * 45000, beta-subunit, SDS-PAGE | Rhizobium etli |
74000 | - |
x * 74000, alpha-subunit, + x * 45000, beta-subunit, SDS-PAGE | Rhizobium etli |
620000 | - |
gel filtration | Rhizobium etli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + acetyl-CoA + HCO3- | Rhizobium etli | - |
ADP + malonyl-CoA + phosphate | - |
? | |
ATP + acetyl-CoA + HCO3- | Rhizobium etli 12-53 | - |
ADP + malonyl-CoA + phosphate | - |
? | |
ATP + butyryl-CoA + HCO3- + H+ | Rhizobium etli | - |
ADP + glutaryl-CoA + phosphate | - |
? | |
ATP + butyryl-CoA + HCO3- + H+ | Rhizobium etli 12-53 | - |
ADP + glutaryl-CoA + phosphate | - |
? | |
ATP + propionyl-CoA + HCO3- + H+ | Rhizobium etli | participation in an anaplerotic pathway causes preference for propionyl-CoA as substrate | ADP + succinyl-CoA + phosphate | - |
? | |
additional information | Rhizobium etli | the enzyme is bifunctional exhibiting both acetyl-CoA carboxylase and propionyl-CoA carboxylase, EC 6.4.1.3, activities | ? | - |
? | |
additional information | Rhizobium etli 12-53 | the enzyme is bifunctional exhibiting both acetyl-CoA carboxylase and propionyl-CoA carboxylase, EC 6.4.1.3, activities | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rhizobium etli | - |
the activities of EC 6.4.1.2 and EC 6.4.1.3 are located on a single protein | - |
Rhizobium etli 12-53 | - |
the activities of EC 6.4.1.2 and EC 6.4.1.3 are located on a single protein | - |
Purification (Comment) | Organism |
---|---|
478fold by ammonium sulfate fractionation, ion exchange chromatography, ultrafiltration, and gel filtration | Rhizobium etli |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA | the enzyme is bifunctional exhibiting both acetyl-CoA carboxylase and propionyl-CoA carboxylase, EC 6.4.1.3, activities | Rhizobium etli |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0004 | - |
acetyl-CoA carboxylase activity, strain CE3 | Rhizobium etli |
0.0005 | - |
acetyl-CoA carboxylase activity, strain 12-53 | Rhizobium etli |
0.001 | - |
acetyl-CoA carboxylase activity, strain CFNX218 | Rhizobium etli |
0.006 | - |
propionyl-CoA carboxylase activity, strain CE3 | Rhizobium etli |
0.0064 | - |
propionyl-CoA carboxylase activity, strain 12-53 | Rhizobium etli |
0.0078 | - |
propionyl-CoA carboxylase activity, strain CFNX218 | Rhizobium etli |
7.27 | - |
purified enzyme, substrate propionyl-CoA | Rhizobium etli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + acetyl-CoA + HCO3- | - |
Rhizobium etli | ADP + malonyl-CoA + phosphate | - |
? | |
ATP + acetyl-CoA + HCO3- | - |
Rhizobium etli 12-53 | ADP + malonyl-CoA + phosphate | - |
? | |
ATP + butyryl-CoA + HCO3- + H+ | - |
Rhizobium etli | ADP + glutaryl-CoA + phosphate | - |
? | |
ATP + butyryl-CoA + HCO3- + H+ | - |
Rhizobium etli 12-53 | ADP + glutaryl-CoA + phosphate | - |
? | |
ATP + propionyl-CoA + HCO3- + H+ | highly preferred substrate | Rhizobium etli | ADP + succinyl-CoA + phosphate | - |
? | |
ATP + propionyl-CoA + HCO3- + H+ | participation in an anaplerotic pathway causes preference for propionyl-CoA as substrate | Rhizobium etli | ADP + succinyl-CoA + phosphate | - |
? | |
additional information | the enzyme is bifunctional exhibiting both acetyl-CoA carboxylase and propionyl-CoA carboxylase, EC 6.4.1.3, activities | Rhizobium etli | ? | - |
? | |
additional information | the enzyme is bifunctional exhibiting both acetyl-CoA carboxylase and propionyl-CoA carboxylase, EC 6.4.1.3, activities | Rhizobium etli 12-53 | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
oligomer | x * 74000, alpha-subunit, + x * 45000, beta-subunit, SDS-PAGE | Rhizobium etli |
Synonyms | Comment | Organism |
---|---|---|
ACC | - |
Rhizobium etli |
More | c.f. EC 6.4.1.3 | Rhizobium etli |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Rhizobium etli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | dependent on | Rhizobium etli | |
biotin | dependent on | Rhizobium etli |