Literature summary for 6.4.1.2 extracted from

Baez-Saldana, A.; Zendejas-Ruiz, I.; Revilla-Monsalve, C.; Islas-Andrade, S.; Cardenas, A.; Rojas-Ochoa, A.; Vilches, A.; Fernandez-Mejia, C.
Effects of biotin on pyruvate carboxylase, acetyl-CoA carboxylase, propionyl-CoA carboxylase, and markers for glucose and lipid homeostasis in type 2 diabetic patients and nondiabetic subjects (2004), Am. J. Clin. Nutr., 79, 238-243.

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Activating Compound

Activating Compound	Comment	Organism	Structure
biotin	induces the enzyme	Homo sapiens
additional information	the enzyme is not affected by D-glucose, insulin, triacylglycerol, cholesterol, or lactate	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	the enzyme is not affected by D-glucose, insulin, triacylglycerol, cholesterol, or lactate	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	the enzyme is critical in gluconeogenesis and lipid synthesis, nondiabetic and type 2 diabetic individuals show similar enzyme activity	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
lymphocyte	circulating, of nondiabetic and type 2 diabetic individuals, female and male	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the enzyme is critical in gluconeogenesis and lipid synthesis, nondiabetic and type 2 diabetic individuals show similar enzyme activity	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
ACC	-	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8	-	assay at	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

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Release 2023.1 (January 2023)