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Literature summary for 6.4.1.2 extracted from

  • Menendez, C.; Bauer, Z.; Huber, H.; Gad'on, N.; Stetter, K.O.; Fuchs, G.
    Presence of acetyl coenzyme A (CoA) carboxylase and propionyl-CoA carboxylase in autotrophic Crenarchaeota and indication for operation of a 3-hydroxypropionate cycle in autotrophic carbon fixation (1999), J. Bacteriol., 181, 1088-1098.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.4.1.2

Inhibitors

Inhibitors Comment Organism Structure
Avidin complete inhibition at 1 nM Metallosphaera sedula

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ complex with ATP Chloroflexus aurantiacus
Mg2+ complex with ATP Metallosphaera sedula
Mg2+ complex with ATP Sulfuracidifex metallicus
Mg2+ complex with ATP Acidianus infernus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + acetyl-CoA + HCO3- Chloroflexus aurantiacus no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation ADP + phosphate + malonyl-CoA
-
 ?
ATP + acetyl-CoA + HCO3- Metallosphaera sedula no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation ADP + phosphate + malonyl-CoA
-
 ?
ATP + acetyl-CoA + HCO3- Sulfuracidifex metallicus no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation ADP + phosphate + malonyl-CoA
-
 ?
ATP + acetyl-CoA + HCO3- Acidianus infernus no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation ADP + phosphate + malonyl-CoA
-
 ?
ATP + acetyl-CoA + HCO3- Acidianus infernus So4a / DSM 3191 no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation ADP + phosphate + malonyl-CoA
-
 ?
ATP + acetyl-CoA + HCO3- Sulfuracidifex metallicus Kra23 / DSM 6482 no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation ADP + phosphate + malonyl-CoA
-
 ?
ATP + acetyl-CoA + HCO3- Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348 no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation ADP + phosphate + malonyl-CoA
-
 ?
ATP + acetyl-CoA + HCO3- Chloroflexus aurantiacus OK-70-fl / DSM 636 no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation ADP + phosphate + malonyl-CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Acidianus infernus
-
-
-
Acidianus infernus So4a / DSM 3191
-
-
-
Chloroflexus aurantiacus
-
-
-
Chloroflexus aurantiacus OK-70-fl / DSM 636
-
-
-
Metallosphaera sedula
-
-
-
Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348
-
-
-
Sulfuracidifex metallicus
-
-
-
Sulfuracidifex metallicus Kra23 / DSM 6482
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0002
-
 crude extract, pH 7.8, 60°C Acidianus infernus
0.0025
-
 crude extract, pH 7.8, 60°C Sulfuracidifex metallicus
0.013
-
 crude extract, pH 7.8, 55°C Metallosphaera sedula
0.015
-
 crude extract, pH 7.8, 55°C Chloroflexus aurantiacus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetyl-CoA + HCO3-
-
 Chloroflexus aurantiacus ADP + phosphate + malonyl-CoA
-
 ?
ATP + acetyl-CoA + HCO3-
-
 Metallosphaera sedula ADP + phosphate + malonyl-CoA
-
 ?
ATP + acetyl-CoA + HCO3-
-
 Sulfuracidifex metallicus ADP + phosphate + malonyl-CoA
-
 ?
ATP + acetyl-CoA + HCO3-
-
 Acidianus infernus ADP + phosphate + malonyl-CoA
-
 ?
ATP + acetyl-CoA + HCO3- no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation Chloroflexus aurantiacus ADP + phosphate + malonyl-CoA
-
 ?
ATP + acetyl-CoA + HCO3- no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation Metallosphaera sedula ADP + phosphate + malonyl-CoA
-
 ?
ATP + acetyl-CoA + HCO3- no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation Sulfuracidifex metallicus ADP + phosphate + malonyl-CoA
-
 ?
ATP + acetyl-CoA + HCO3- no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation Acidianus infernus ADP + phosphate + malonyl-CoA
-
 ?
ATP + acetyl-CoA + HCO3-
-
 Acidianus infernus So4a / DSM 3191 ADP + phosphate + malonyl-CoA
-
 ?
ATP + acetyl-CoA + HCO3- no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation Acidianus infernus So4a / DSM 3191 ADP + phosphate + malonyl-CoA
-
 ?
ATP + acetyl-CoA + HCO3-
-
 Sulfuracidifex metallicus Kra23 / DSM 6482 ADP + phosphate + malonyl-CoA
-
 ?
ATP + acetyl-CoA + HCO3- no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation Sulfuracidifex metallicus Kra23 / DSM 6482 ADP + phosphate + malonyl-CoA
-
 ?
ATP + acetyl-CoA + HCO3-
-
 Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348 ADP + phosphate + malonyl-CoA
-
 ?
ATP + acetyl-CoA + HCO3- no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation Metallosphaera sedula TH2 / ATCC 51363 / DSM 5348 ADP + phosphate + malonyl-CoA
-
 ?
ATP + acetyl-CoA + HCO3-
-
 Chloroflexus aurantiacus OK-70-fl / DSM 636 ADP + phosphate + malonyl-CoA
-
 ?
ATP + acetyl-CoA + HCO3- no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation Chloroflexus aurantiacus OK-70-fl / DSM 636 ADP + phosphate + malonyl-CoA
-
 ?

Cofactor

Cofactor Comment Organism Structure
biotin enzyme-bound Chloroflexus aurantiacus
biotin enzyme-bound Metallosphaera sedula
biotin enzyme-bound Sulfuracidifex metallicus
biotin enzyme-bound Acidianus infernus