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Literature summary for 6.4.1.1 extracted from

  • Lazar, N.; Fay, A.; Nandakumar, M.; Boyle, K.E.; Xavier, J.; Rhee, K.; Glickman, M.S.
    Control of biotin biosynthesis in mycobacteria by a pyruvate carboxylase dependent metabolic signal (2017), Mol. Microbiol., 106, 1018-1031 .
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mycolicibacterium smegmatis A0QV14
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Mycolicibacterium smegmatis ATCC 700084 A0QV14
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Synonyms

Synonyms Comment Organism
MSmeg_2412
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Mycolicibacterium smegmatis
PYC
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Mycolicibacterium smegmatis

General Information

General Information Comment Organism
physiological function a gene disruption strain is auxotrohp for biotin due to failure to transcriptionally induce late stage biotin biosynthetic genes in low biotin conditions. Catalytically active Pyc is required and can be supported by Mycobacterium tuberculosis Pyc Mycolicibacterium smegmatis