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Literature summary for 6.4.1.1 extracted from

  • Cheng, T.; Sudderth, J.; Yang, C.; Mullen, A.; Jin, E.; Mates, J.; DeBerardinis, R.
    Pyruvate carboxylase is required for glutamine-independent growth of tumor cells (2011), Proc. Natl. Acad. Sci. USA, 108, 8674-8679.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine induction of pyruvate decarboxylase during chronic suppression of glutamine metabolism is a mechanism of resistance to therapies targeting glutaminolysis Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
guard cell
-
 Homo sapiens
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Hep-G2 cell
-
 Homo sapiens
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Huh-7 cell
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 Homo sapiens
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LN-229 cell
-
 Homo sapiens
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SF-xL cell
-
 Homo sapiens
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General Information

General Information Comment Organism
physiological function pyruvate carboxylase (PC) is required for glutamine-independent growth of tumor cells. PC-mediated, glucose-dependent anaplerosis allows cells to achieve glutamine independence. PC is required for cell growth during glutamine deprivation Homo sapiens