Application | Comment | Organism |
---|---|---|
medicine | treatment of cultured 3T3-L1 adipocytes with inhibitor phenylacetate. Inhibiting the enzyme over several days does not alter the adipocyte differentiation program. The main metabolic effects are to up-regulate intracellular lipolysis and decrease triglyceride accumulation. Inhibition also up-regulates glycolysis. The reduction in triglycerides is due to decreased de novo fatty acid synthesis. Exogenous addition of free fatty acids dose-dependently increases the cellular triglyceride level in the inhibitor-treated adipocytes, but not in untreated control cells | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
phenylacetate | treatment of cultured 3T3-L1 adipocytes. Inhibiting the enzyme over several days does not alter the adipocyte differentiation program. The main metabolic effects are to up-regulate intracellular lipolysis and decrease triglyceride accumulation. Inhibition also up-regulates glycolysis | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
3T3-L1 cell | - |
Mus musculus | - |