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Literature summary for 6.4.1.1 extracted from

  • Si, Y.; Shi, H.; Lee, K.
    Impact of perturbed pyruvate metabolism on adipocyte triglyceride accumulation (2009), Metab. Eng., 11, 382-390.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine treatment of cultured 3T3-L1 adipocytes with inhibitor phenylacetate. Inhibiting the enzyme over several days does not alter the adipocyte differentiation program. The main metabolic effects are to up-regulate intracellular lipolysis and decrease triglyceride accumulation. Inhibition also up-regulates glycolysis. The reduction in triglycerides is due to decreased de novo fatty acid synthesis. Exogenous addition of free fatty acids dose-dependently increases the cellular triglyceride level in the inhibitor-treated adipocytes, but not in untreated control cells Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
phenylacetate treatment of cultured 3T3-L1 adipocytes. Inhibiting the enzyme over several days does not alter the adipocyte differentiation program. The main metabolic effects are to up-regulate intracellular lipolysis and decrease triglyceride accumulation. Inhibition also up-regulates glycolysis Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
3T3-L1 cell
-
Mus musculus
-