Literature summary for 6.4.1.1 extracted from

Fransson, U.; Rosengren, A.H.; Schuit, F.C.; Renstroem, E.; Mulder, H.
Anaplerosis via pyruvate carboxylase is required for the fuel-induced rise in the ATP:ADP ratio in rat pancreatic islets (2006), Diabetologia, 49, 1578-1586.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + pyruvate + HCO3-	Rattus norvegicus	pyruvate carboxylase, and thereby anaplerosis, is crucial for an appropriate rise in the ATP:ADP ratio in response to fuel metabolism	ADP + phosphate + oxaloacetate	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
pancreatic islet	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + pyruvate + HCO3-	-	Rattus norvegicus	ADP + phosphate + oxaloacetate	-	?
ATP + pyruvate + HCO3-	pyruvate carboxylase, and thereby anaplerosis, is crucial for an appropriate rise in the ATP:ADP ratio in response to fuel metabolism	Rattus norvegicus	ADP + phosphate + oxaloacetate	-	?

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Release 2023.1 (January 2023)