Literature summary for 6.4.1.1 extracted from

Peters-Wendisch, P.G.; Schiel, B.; Wendisch, V.F.; Katsoulidis, E.; Mockel, B.; Sahm, H.; Eikmanns, B.J.
Pyruvate carboxylase is a major bottleneck for glutamate and lysine production by Corynebacterium glutamicum (2001), J. Mol. Microbiol. Biotechnol., 3, 295-300.

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Cloned(Commentary)

Cloned (Comment)	Organism
wild-type and mutants without enzyme activity	Corynebacterium glutamicum

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
123000	-	SDS-PAGE	Corynebacterium glutamicum

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + pyruvate + HCO3-	Corynebacterium glutamicum	anaplerotic enzyme for growth on carbohydrates, reaction is a major bottleneck for amino acid production	ADP + phosphate + oxaloacetate	-	?

Organism

Organism	UniProt	Comment	Textmining
Corynebacterium glutamicum	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + pyruvate + HCO3-	-	Corynebacterium glutamicum	ADP + phosphate + oxaloacetate	-	?
ATP + pyruvate + HCO3-	anaplerotic enzyme for growth on carbohydrates, reaction is a major bottleneck for amino acid production	Corynebacterium glutamicum	ADP + phosphate + oxaloacetate	-	?

Synonyms

Synonyms	Comment	Organism
PCx	-	Corynebacterium glutamicum

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Release 2023.1 (January 2023)