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Literature summary for 6.3.5.7 extracted from

  • Echevarria, L.; Clemente, P.; Hernandez-Sierra, R.; Gallardo, M.E.; Fernandez-Moreno, M.A.; Garesse, R.
    Glutamyl-tRNAGln amidotransferase is essential for mammalian mitochondrial translation invivo (2014), Biochem. J., 460, 91-101 .
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Mus musculus Q9CZN8
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-

Synonyms

Synonyms Comment Organism
gatA
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Mus musculus
Qrsl1
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Mus musculus

General Information

General Information Comment Organism
physiological function knock-down of GatA by siRNA produces a strong defect in mitochondrial translation without affecting the stability of the newly synthesized proteins. Interfered cells present an impairment of the oxidative phosphorylation system and a significant increase in ROS levels. Mitochondrial proteins have no glutamic acid in the position of glutamines Mus musculus