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Literature summary for 6.3.5.5 extracted from

  • Sato, T.; Akasu, H.; Shimono, W.; Matsu, C.; Fujiwara, Y.; Shibagaki, Y.; Heard, J.J.; Tamanoi, F.; Hattori, S.
    Rheb protein binds CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, and dihydroorotase) protein in a GTP- and effector domain-dependent manner and influences its cellular localization and carbamoyl-phosphate synthetase (CPSase) activity (2015), J. Biol. Chem., 290, 1096-1105 .
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol presence in the cytosol surrounding the nucleus, plus partial localization in the lysosome Homo sapiens 5829
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lysosome coexpression of small GTPase Rheb with CAD leads to increased accumulation of CAD on lysosomes Homo sapiens 5764
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nucleus both a farnesyltransferase inhibitor that blocks membrane association of Rheb and knockdown of Rheb mislocalize CAD to the nucleus Homo sapiens 5634
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Organism

Organism UniProt Comment Textmining
Homo sapiens P27708 gene encodes four enzymatic activities of the pyrimidine pathway, i.e. GATase, CPSase, ATCase and DHOase
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Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
CAD
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 Homo sapiens

General Information

General Information Comment Organism
physiological function small GTPases Rheb1 and Rheb2 bind to CAD. Binding is more pronounced with Rheb2 than with Rheb1. Rheb binds CAD in a GTP- and effector domain-dependent manner. Rheb binds at the C-terminal region of the carbamoyl-phosphate synthetase domain and not in the dihydroorotase and aspartate transcarbamoylase domains. Rheb stimulates carbamoyl-phosphate synthetase activity of CAD in vitro. Expression of Rheb leads to increased accumulation of CAD on lysosomes Homo sapiens