Literature summary for 6.3.5.5 extracted from

Borawski, J.; Troke, P.; Puyang, X.; Gibaja, V.; Zhao, S.; Mickanin, C.; Leighton-Davies, J.; Wilson, C.J.; Myer, V.; Cornellataracido, I.; Baryza, J.; Tallarico, J.; Joberty, G.; Bantscheff, M.; Schirle, M.; Bouwmeester, T.; Mathy, J.E.; Lin, K.; Compton, T.; Labow, M.; Wiedmann, B.; Gaither, L.A.
Class III phosphatidylinositol 4-kinase alpha and beta are novel host factor regulators of hepatitis C virus replication (2009), J. Virol., 83, 10058-10074.

Protein Variants

Protein Variants	Comment	Organism
additional information	downregulation of CAD, i.e. carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase, by specific siRNA	Hepacivirus C

Inhibitors	Comment	Organism	Structure
leflunomide	-	Hepacivirus C
additional information	both the Luc-1b replicon and JFH1-2a virus expression inhibit CAD	Hepacivirus C

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Hepacivirus C	the enzyme is organized as CAD, i.e. carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase, a tripartite enzyme that catalyzes the first three steps of pyrimidine biosynthesis	?	-	?

Organism	UniProt	Comment	Textmining
Hepacivirus C	-	HCV, gene CAD	-

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the enzyme is organized as CAD, i.e. carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase, a tripartite enzyme that catalyzes the first three steps of pyrimidine biosynthesis	Hepacivirus C	?	-	?

Synonyms	Comment	Organism
carbamoyl-phosphate synthetase 2	-	Hepacivirus C

Cofactor	Comment	Organism	Structure
ATP	-	Hepacivirus C

General Information	Comment	Organism
metabolism	the enzyme is organized as CAD, i.e. carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase, a tripartite enzyme that catalyzes the first three steps of pyrimidine biosynthesis	Hepacivirus C
physiological function	the enzyme is essential for HCV infection and replication in human liver cells	Hepacivirus C