Literature summary for 6.3.5.5 extracted from

Simmons, C.Q.; Simmons, A.J.; Haubner, A.; Ream, A.; Davidson, J.N.
Substitutions in hamster CAD carbamoyl-phosphate synthetase alter allosteric response to 5-phosphoribosyl-alpha-pyrophosphate (PRPP) and UTP (2004), Biochem. J., 378, 991-998.

Search for more literature for 6.3.5.5

Activating Compound

Activating Compound	Comment	Organism	Structure
5-phospho-alpha-D-ribose 1-diphosphate	activates wild-type enzyme	Cricetulus griseus

Protein Variants

Protein Variants	Comment	Organism
K954E	enzyme activity in absence of effectors is slightly lower when compared with the enzyme from wild-type. UTP inhibition is reduced	Cricetulus griseus
S974A	under conditions of saturating Utp (2 mM), mutant enzyme shows similar degree of inhibition as wild-type enzyme. Activation by 5-phosphoribosyl-alpha-pyrophosphate is completely abolished at 0.05 mM, a concentration where near maximal activation is observed with wild-type enzyme	Cricetulus griseus

Inhibitors

Inhibitors	Comment	Organism	Structure
UTP	-	Cricetulus griseus

Organism

Organism	UniProt	Comment	Textmining
Cricetulus griseus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
CHO-K1 cell	G9C line	Cricetulus griseus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2 ATP + L-Gln + HCO3-	-	Cricetulus griseus	2 ADP + phosphate + L-Glu + carbamoyl phosphate	-	?

Synonyms

Synonyms	Comment	Organism
CAD carbamoyl-phosphate synthetase	-	Cricetulus griseus

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Release 2023.1 (January 2023)