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Literature summary for 6.3.5.5 extracted from

  • Raushel, F.M.; Thoden, J.B.; Reinhart, G.D.; Holden, H.M.
    Carbamoyl phosphate synthetase: a crooked path from substrates to products (1998), Curr. Opin. Chem. Biol., 2, 624-632.
    View publication on PubMed
Search for more literature for 6.3.5.5

Activating Compound

Activating Compound Comment Organism Structure
ornithine
-
 Escherichia coli

Crystallization (Commentary)

Crystallization (Comment) Organism
the three active sites within the alpha,beta heterodimer are separated by a linear distance of nearly 100 A and are interconnected by two molecular tunnels Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
IMP binds with good affinity to the enzyme, small effect below 35°C Escherichia coli
UMP
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 ATP + L-Gln + HCO3- Escherichia coli the product carbamoyl phosphate plays a critical role in both arginine and pyrimidine biosynthesis 2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Reaction

Reaction Comment Organism Reaction ID
2 ATP + L-glutamine + hydrogencarbonate + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate pathway, relationship between mechanism and structure Escherichia coli
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ATP + L-Gln + HCO3-
-
 Escherichia coli 2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
 ir
2 ATP + L-Gln + HCO3- the product carbamoyl phosphate plays a critical role in both arginine and pyrimidine biosynthesis Escherichia coli 2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
 ?
2 ATP + NH4+ + HCO3-
-
 Escherichia coli 2 ADP + phosphate + carbamoyl phosphate
-
 ir

Subunits

Subunits Comment Organism
heterodimer alpha,beta, the small subunit is able to catalyze the hydrolysis of glutamine, the large subunit catalyses the formation of carbamoyl phosphate using ammonia as a nitrogen source Escherichia coli