Activating Compound | Comment | Organism | Structure |
---|---|---|---|
IMP | His995, located in the C-terminal regulatory domain, is cross-linked with IMP | Escherichia coli | |
ornithine | - |
Escherichia coli |
Protein Variants | Comment | Organism |
---|---|---|
H995A | mutant exhibits normal kinetics for the activator ornithine and for the substrates in presence of ornithine, the mutation selectiviely decrease 5.6 and 2.3fold the apparent affinity for UMP and IMP, mutation abolishes the ability to be photoaffinity labeled with IMP | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
UMP | Lys993 is cross-linked with UMP | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 ATP + L-Gln + HCO3- | Escherichia coli | the product carbamoyl phosphate is an essential precursor of arginine and pyrimidine biosynthesis | 2 ADP + phosphate + L-Glu + carbamoyl phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 ATP + L-Gln + HCO3- | - |
Escherichia coli | 2 ADP + phosphate + L-Glu + carbamoyl phosphate | - |
? | |
2 ATP + L-Gln + HCO3- | the product carbamoyl phosphate is an essential precursor of arginine and pyrimidine biosynthesis | Escherichia coli | 2 ADP + phosphate + L-Glu + carbamoyl phosphate | - |
? | |
2 ATP + NH4+ + HCO3- | - |
Escherichia coli | 2 ADP + phosphate + carbamoyl phosphate | - |
? |