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Literature summary for 6.3.5.5 extracted from

  • Thoden, J.B.; Miran, S.G.; Phillips, J.C.; Howard, A.J.; Raushel, F.M.; Holden, H.M.
    Carbamoyl phosphate synthetase: caught in the act of glutamine hydrolysis (1998), Biochemistry, 37, 8825-8831.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
X-ray crystallographic structure Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 ATP + L-Gln + HCO3- Escherichia coli
-
2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Reaction

Reaction Comment Organism Reaction ID
2 ATP + L-glutamine + hydrogencarbonate + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate reaction pathway of the enzyme small subunit proceeds through the formation of the glutamyl thioester intermediate Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ATP + L-Gln + HCO3-
-
Escherichia coli 2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
?
2 ATP + NH4+ + HCO3-
-
Escherichia coli 2 ADP + phosphate + carbamoyl phosphate
-
?

Subunits

Subunits Comment Organism
heterodimer the small subunit belongs to the class I amidotransferase family of enzymes, the reaction mechanism of the small subunit proceeds through the formation of the glutamyl thioester intermediate Escherichia coli