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Literature summary for 6.3.5.5 extracted from

  • Trotta, P.P; Estis, L.F.; Meister, A.; Haschemeyer, R.H.
    Self-association and allosteric properties of glutamine-dependent carbamyl phosphate synthetase (1974), J. Biol. Chem., 249, 482-491.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
guanidine hydrochloride
-
Escherichia coli
Urea
-
Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
NH4+ positive allosteric effector of Gln-dependent activity, promotes self-association of the enzyme Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ATP + L-Gln + HCO3-
-
Escherichia coli 2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
?

Subunits

Subunits Comment Organism
More NH4+ or Orn promotes oligomer formation. Tetramer or higher oligomeric species in potassium phosphate buffer containing Orn Escherichia coli