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Literature summary for 6.3.5.4 extracted from
- An alternative mechanism for the nitrogen transfer reaction in Asparagine+ synthetase (1992), FEBS Lett., 313, 98-102.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
wild-type and mutant enzymes C99A, C168A, C386A, C423A, C436A, C514A, C523A | - |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| ATP + L-aspartate + L-glutamine + H2O = AMP + diphosphate + L-asparagine + L-glutamate | a model for the role of the catalytic triad in transferring nitrogen from Gln to Asp. An alternative catalytic mechanism is proposed, which obviates the participation of a histidine residue in the reaction | Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-Asp + L-Gln | - |
Escherichia coli | AMP + diphosphate + Asn + Glu | - |
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