Literature summary for 6.3.4.5 extracted from

Huang, Z.; Wang, T.S.; Zhao, Y.C.; Zuo, R.J.; Deng, W.B.; Chi, Y.J.; Yang, Z.M.
Cyclic adenosine monophosphate-induced argininosuccinate synthase 1 expression is essential during mouse decidualization (2014), Mol. Cell. Endocrinol., 388, 20-31 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
alpha-methyl-DL-aspartic acid	specific inhibitor for Ass1, can significantly increase the rate of embryonic reabsorption	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	P16460	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
decidua	Ass1 is highly expressed in mouse decidua and uterine stromal cells undergoing decidualization, and argininosuccinate lyase Asl is weakly expressed in mouse decidua and uterine stromal cells undergoing decidualization	Mus musculus	-
uterus	Ass1 is highly expressed in mouse decidua and uterine stromal cells undergoing decidualization, and argininosuccinate lyase Asl is weakly expressed in mouse decidua and uterine stromal cells undergoing decidualization	Mus musculus	-

Expression

Organism	Comment	Expression
Mus musculus	L-Arg at high concentration down-regulates Ass1 and Asl expression by negative feedback to maintain L-Arg homeostasis	down
Mus musculus	Ass1 expression is upregulated significantly at implantation site on day 5 of pregnancy. Ass1 expression is induced by cAMP through PKA/p-Creb signaling pathway	up

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Release 2023.1 (January 2023)