Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P00966 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HUVEC cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
ASS1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | exogenous expression of either nitric oxide synthase NOS3 or argininosuccinate synthetaseASS1 increases NO production and decreases monocyte adhesion stimulated by tumor necrosis factor-alpha. The latter effect is reduced when human umbilical vein endothelial cells are co-treated with small interfering RNAs for ASS1 or NOS3. SiRNAs of NOS3 and ASS1 attenuate the increase of NO production in human aortic endothelial cells stimulated by laminar shear stress for 24 h | Homo sapiens |