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Literature summary for 6.3.4.5 extracted from

  • Mun, G.I.; Kim, I.S.; Lee, B.H.; Boo, Y.C.
    Endothelial argininosuccinate synthetase 1 regulates nitric oxide production and monocyte adhesion under static and laminar shear stress conditions (2011), J. Biol. Chem., 286, 2536-2542.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens P00966
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-

Source Tissue

Source Tissue Comment Organism Textmining
HUVEC cell
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Homo sapiens
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Synonyms

Synonyms Comment Organism
ASS1
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Homo sapiens

General Information

General Information Comment Organism
physiological function exogenous expression of either nitric oxide synthase NOS3 or argininosuccinate synthetaseASS1 increases NO production and decreases monocyte adhesion stimulated by tumor necrosis factor-alpha. The latter effect is reduced when human umbilical vein endothelial cells are co-treated with small interfering RNAs for ASS1 or NOS3. SiRNAs of NOS3 and ASS1 attenuate the increase of NO production in human aortic endothelial cells stimulated by laminar shear stress for 24 h Homo sapiens