Application | Comment | Organism |
---|---|---|
medicine | potential target in platinum sensitive tumours | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
caveola | - |
Homo sapiens | 5901 | - |
cytosol | - |
Homo sapiens | 5829 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
carcinoma cell line | - |
Homo sapiens | - |
endothelial cell | - |
Homo sapiens | - |
inflammatory cell | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
Argininosuccinate synthetase | - |
Homo sapiens |
ASS1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | tumoural enzyme downregulation by hepatocellular carcinoma, malignant melanoma, malignant pleural mesothelioma, prostate and renal cancer | down |
Homo sapiens | hepatic argininosuccinate synthase expression is hormonally regulated, expression of endothelial and inflammatory cell argininosuccinate synthase is under control of cytokines | additional information |
Homo sapiens | overexpression of argininosuccinate synthase in primary ovarian, stomach and colorectal cancer cells results in platinum sensitive tumours | up |
General Information | Comment | Organism |
---|---|---|
malfunction | epigenetic silencing triggers apoptosis in arginine auxotroph tumours | Homo sapiens |
physiological function | rate-limiting enzyme in urea and arginine(NO)-citrulline cycles | Homo sapiens |