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Literature summary for 6.3.4.5 extracted from

  • Corbin, K.D.; Pendleton, L.C.; Solomonson, L.P.; Eichler, D.C.
    Phosphorylation of argininosuccinate synthase by protein kinase A (2008), Biochem. Biophys. Res. Commun., 377, 1042-1046.
    View publication on PubMed
Search for more literature for 6.3.4.5

Cloned(Commentary)

Cloned (Comment) Organism
expression of the His-tagged enzyme in Escherichia coli Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-citrulline + L-aspartate Bos taurus argininosuccinate synthase is essential for endothelial nitric oxide production, vascular NO production is regulated by dynamic argininosuccinate synthase phosphorylation AMP + diphosphate + 2-(Nomega-L-arginino)succinate
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein regulation of argininosuccinate synthase by dynamic phosphorylation through protein kinase A, the enzyme lacks a consensus Akt phosphorylation motif R-X-R-X-X-S/T Bos taurus

Purification (Commentary)

Purification (Comment) Organism
recombinant His-tagged enzyme from Escherichia coli by nickel affinty chromatography Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
aorta
-
 Bos taurus
-
endothelial cell aortic Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-citrulline + L-aspartate
-
 Bos taurus AMP + diphosphate + 2-(Nomega-L-arginino)succinate
-
 ?
ATP + L-citrulline + L-aspartate argininosuccinate synthase is essential for endothelial nitric oxide production, vascular NO production is regulated by dynamic argininosuccinate synthase phosphorylation Bos taurus AMP + diphosphate + 2-(Nomega-L-arginino)succinate
-
 ?

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Bos taurus