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Literature summary for 6.3.4.5 extracted from

  • Goodwin, B.L.; Corbin, K.D.; Pendleton, L.C.; Levy, M.M.; Solomonson, L.P.; Eichler, D.C.
    Troglitazone up-regulates vascular endothelial argininosuccinate synthase (2008), Biochem. Biophys. Res. Commun., 370, 254-258.
    View publication on PubMed
Search for more literature for 6.3.4.5

Activating Compound

Activating Compound Comment Organism Structure
additional information troglitazone, a PPARgamma ligand, and thiazolidinedione up-regulate vascular endothelial argininosuccinate synthase expression, quantitative real time RT-PCR, overview Bos taurus

Cloned(Commentary)

Cloned (Comment) Organism
expression analysis, the AS gene promoter contains a a near consensus PPARgamma response element, PPRE, overview Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
additional information 1-D-ribofuranosylbenzimidazole suppresses enzyme expression Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-citrulline + L-aspartate Bos taurus the caveolar-localized endothelial argininosuccinate synthase catalyzes the rate-limiting step of the citrulline-NO cycle, involving not only the regulation of endothelial nitric oxide synthase, but also regulation of cycle, overview AMP + diphosphate + 2-(Nomega-L-arginino)succinate
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta
-
 Bos taurus
-
endothelial cell aortic Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-citrulline + L-aspartate
-
 Bos taurus AMP + diphosphate + 2-(Nomega-L-arginino)succinate
-
 ?
ATP + L-citrulline + L-aspartate the caveolar-localized endothelial argininosuccinate synthase catalyzes the rate-limiting step of the citrulline-NO cycle, involving not only the regulation of endothelial nitric oxide synthase, but also regulation of cycle, overview Bos taurus AMP + diphosphate + 2-(Nomega-L-arginino)succinate
-
 ?

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Bos taurus