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Literature summary for 6.3.4.5 extracted from

  • Hukkanen, M.; Platts, L.A.M.; Haralambous, S.; Ainola, M.; Konttinen, Y.T.; Kollias, G.; Polak, J.M.
    Induction of inducible nitric oxide synthase, argininosuccinate synthase, and GTP cyclohydrolase I in arthritic joints of human tumor necrosis factor-alpha transgenic mice (2003), J. Rheumatol., 30, 652-659.
    View publication on PubMed
Search for more literature for 6.3.4.5

Activating Compound

Activating Compound Comment Organism Structure
additional information inducible enzyme, immunostimulation of AS synthesis with lipopolysaccharide or cytokines, such as TNF-alpha, interleukin 1 and interferon-gamma Mus musculus

Application

Application Comment Organism
medicine AS and GTP cyclohydrolase I are intimately associated with inflammatory arthritis, they may be important modulators of arthritis and may represent novel targets for modulation of disease activity Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus involved in L-arginine synthesis from L-citrulline, urea cycle, rate-limiting enzyme for high output NO generation, inducible enzyme, AS synthesis is more strictly regulated at the posttranscriptional than the transcriptional level in vivo ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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 human tumor necrosis factor-alpha transgenic mice, 4 and 8 weeks old, and age-matched CBA x C57B1/6 wild-type controls
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information involved in L-arginine synthesis from L-citrulline, urea cycle, rate-limiting enzyme for high output NO generation, inducible enzyme, AS synthesis is more strictly regulated at the posttranscriptional than the transcriptional level in vivo Mus musculus ?
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 ?

Synonyms

Synonyms Comment Organism
Argininosuccinate synthetase
-
 Mus musculus
AS
-
 Mus musculus