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Literature summary for 6.3.4.5 extracted from
- Kinetic mechanism of argininosuccinate synthetase (1983), Arch. Biochem. Biophys., 225, 979-985.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| AMP | - |
Bos taurus |  |
| diphosphate | - |
Bos taurus | |
| L-argininosuccinate | - |
Bos taurus | |
| Methylaspartate | - |
Bos taurus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| ATP + L-citrulline + L-aspartate = AMP + diphosphate + 2-(Nomega-L-arginino)succinate | ordered addition of MgATP2-, citrulline, and aspartate, followed by ordered release of argininosuccinate, magnesiumdiphosphate and AMP | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-citrulline + 3-nitro-2-aminopropanoate | 60% of the maximal activity with Asp | Bos taurus | ? | - |
? | |
| ATP + L-citrulline + L-Asp | - |
Bos taurus | AMP + diphosphate + L-argininosuccinate | - |
? | |
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Release 2023.1 (January 2023)
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