Literature summary for 6.3.4.5 extracted from

Takada, S.; Saheki, T.; Igarashi, Y.; Katsunuma, T.
Studies on rat liver argininosuccinate synthetase. Inhibition by various amino acids (1979), J. Biochem., 85, 1309-1314.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
-	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
2-aminopentanoic acid	competitive to L-citrulline	Rattus norvegicus
L-Arg	competitive to L-Asp; competitive with L-citrulline	Rattus norvegicus
L-argininosuccinate	competitive to L-Asp	Rattus norvegicus
L-His	-	Rattus norvegicus
L-Ile	competitive to L-citrulline	Rattus norvegicus
L-Trp	-	Rattus norvegicus
L-Val	competitive to L-citrulline	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + L-citrulline + L-Asp	-	Rattus norvegicus	AMP + diphosphate + L-argininosuccinate	-	?

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Release 2023.1 (January 2023)