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Literature summary for 6.3.4.4 extracted from

  • Wang, X.; Wang, G.; Li, X.; Fu, J.; Chen, T.; Wang, Z.; Zhao, X.
    Directed evolution of adenylosuccinate synthetase from Bacillus subtilis and its application in metabolic engineering (2016), J. Biotechnol., 231, 115-121 .
    View publication on PubMed

Application

Application Comment Organism
synthesis expression of mutant P242N in an inosine-producing strain results in an approximately 4.66fold increase in inosine production, to 0.41 g/L, in minimal medium without hypoxanthine accumulation Bacillus subtilis

Protein Variants

Protein Variants Comment Organism
P242N about 50% of wild-type activity. Mutant partially reduces the flux towards AMP derived from IMP and increases the riboflavin synthesis precursor GTP Bacillus subtilis

Organism

Organism UniProt Comment Textmining
Bacillus subtilis P29726
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Bacillus subtilis 168 P29726
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Synonyms

Synonyms Comment Organism
purA
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Bacillus subtilis