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Literature summary for 6.3.4.4 extracted from

  • Eaazhisai, K.; Jayalakshmi, R.; Gayathri, P.; Anand, R.P.; Sumathy, K.; Balaram, H.; Murthy, M.R.
    Crystal structure of fully ligated adenylosuccinate synthetase from Plasmodium falciparum (2004), J. Mol. Biol., 335, 1251-1264.
    View publication on PubMed
Search for more literature for 6.3.4.4

Application

Application Comment Organism
medicine enzymes of the salvage pathway are good targets for anti-parasitic drugs Plasmodium falciparum

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 (DE3) Plasmodium falciparum

Crystallization (Commentary)

Crystallization (Comment) Organism
space group C222(1), cell parameters a = 91.58 A, b = 117.12 A, c = 80.42A Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
Hadacidin
-
 Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + IMP + L-aspartate Plasmodium falciparum salvage pathway, catalyzing the first committed step in the synthesis of AMP from IMP GDP + phosphate + adenylosuccinate
-
 ?

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum Q9U8D3
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Plasmodium falciparum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + IMP + L-aspartate
-
 Plasmodium falciparum GDP + phosphate + adenylosuccinate
-
 ?
GTP + IMP + L-aspartate salvage pathway, catalyzing the first committed step in the synthesis of AMP from IMP Plasmodium falciparum GDP + phosphate + adenylosuccinate
-
 ?

Subunits

Subunits Comment Organism
dimer
-
 Plasmodium falciparum

Synonyms

Synonyms Comment Organism
Adenylosuccinate synthetase
-
 Plasmodium falciparum
AdSS
-
 Plasmodium falciparum
PfAdSS
-
 Plasmodium falciparum