Literature summary for 6.3.4.4 extracted from

Lee, P.; Gorrell, A.; Fromm, H.J.; Colman, R.F.
Implication of arginine-131 and arginine-303 in the substrate site of adenylosuccinate synthetase of Escherichia coli by affinity labeling with 6-(4-bromo-2,3-dioxobutyl)thioadenosine 5'-monophosphate (1999), Biochemistry, 38, 5754-5763.

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Inhibitors

Inhibitors	Comment	Organism	Structure
6-(4-bromo-2,3-dioxobutyl)thioadenosine 5'-monophosphate	-	Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
GTP + IMP + L-aspartate	Escherichia coli	catalyzes the first step in the conversion of IMP to AMP in de novo purine nucleotide metabolism	GDP + phosphate + adenylosuccinate	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GTP + IMP + L-aspartate	-	Escherichia coli	GDP + phosphate + adenylosuccinate	-	?
GTP + IMP + L-aspartate	catalyzes the first step in the conversion of IMP to AMP in de novo purine nucleotide metabolism	Escherichia coli	GDP + phosphate + adenylosuccinate	-	?

Synonyms

Synonyms	Comment	Organism
Adenylosuccinate synthetase	-	Escherichia coli

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0406	-	6-(4-bromo-2,3-dioxobutyl)thioadenosine 5'-monophosphate	pH 7.0, 25°C	Escherichia coli

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Release 2023.1 (January 2023)