Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.3.4.3 extracted from

  • Sugiura, T.; Nagano, Y.; Inoue, T.; Hirotani, K.
    A novel mitochondrial C1-tetrahydrofolate synthetase is upregulated in human colon adenocarcinoma (2004), Biochem. Biophys. Res. Commun., 315, 204-211.
    View publication on PubMed
Search for more literature for 6.3.4.3

Application

Application Comment Organism
pharmacology the enzyme might be a target for colorectal cancer therapy Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene DKFZp586G1517, DNA and amino acid sequence determination and analysis, overexpression of mitochondrial enzyme in HEK-293 cells, unlabeled or FLAG-tagged, stimulates cell growth Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion mitochondrial isozyme, contains an N-terminal mitochondrial targeting sequence Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme may participate in the progression of colorectal cancer by conferring growth advantage ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q6UB35 trifunctional enzyme
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme is partially purified from HEK-293 cells by subcellular fractionation Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
breast higher expression level Homo sapiens
-
colon
-
 Homo sapiens
-
colonic adenocarcinoma cell 2fold increased expression of gene DKFZp586G1517 compared to normal colon tissue Homo sapiens
-
erythrocyte low expression level Homo sapiens
-
kidney
-
 Homo sapiens
-
liver
-
 Homo sapiens
-
lung higher expression level Homo sapiens
-
lymphocyte low expression level Homo sapiens
-
ovary high expression level Homo sapiens
-
pancreas
-
 Homo sapiens
-
prostate
-
 Homo sapiens
-
skeletal muscle low expression level Homo sapiens
-
small intestine higher expression level Homo sapiens
-
spleen
-
 Homo sapiens
-
stomach
-
 Homo sapiens
-
thymus
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme may participate in the progression of colorectal cancer by conferring growth advantage Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
C1-tetrahydrofolate synthetase
-
 Homo sapiens
C1-THFS
-
 Homo sapiens