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Literature summary for 6.3.4.3 extracted from

  • Prasannan, P.; Pike, S.; Peng, K.; Shane, B.; Appling, D.R.
    Human mitochondrial C1-tetrahydrofolate synthase: gene structure, tissue distribution of the mRNA, and immunolocalization in Chinese hamster ovary calls (2003), J. Biol. Chem., 278, 43178-43187.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.3.4.3

Cloned(Commentary)

Cloned (Comment) Organism
expression in CHO cells and Saccharomyces cerevisiae Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + formate + tetrahydrofolate Homo sapiens
-
 ADP + phosphate + 10-formyltetrahydrofolate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q6UB35
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain high transcript levels Homo sapiens
-
liver low transcript levels Homo sapiens
-
placenta high transcript levels Homo sapiens
-
skeletal muscle low transcript levels Homo sapiens
-
thymus high transcript levels Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + formate + tetrahydrofolate
-
 Homo sapiens ADP + phosphate + 10-formyltetrahydrofolate
-
 ?
ATP + formate + tetrahydrofolate trifuntional enzyme having 10-formyl-tetrahydrofolate synthetase, 5,10-methylene-tetrahydrofolate cyclohydrolase and 5,10-methylene-tetrahydrofolate dehydrogenase activity Homo sapiens ADP + phosphate + 10-formyltetrahydrofolate
-
 ?

Synonyms

Synonyms Comment Organism
C1-tetrahydrofolate synthase
-
 Homo sapiens