Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.3.4.21 extracted from

  • Grubmeyer, C.T.; Gross, J.W.; Rajavel, M.
    Energy coupling through molecular discrimination: nicotinate phosphoribosyltransferase (1999), Methods Enzymol., 308, 28-48.
    View publication on PubMed
Search for more literature for 6.3.4.21

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
45530
-
 predicted from DNA sequence Salmonella enterica subsp. enterica serovar Typhimurium

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WJW5
-
-
Mycobacterium tuberculosis H37Rv P9WJW5
-
-
Saccharomyces cerevisiae
-
-
-
Saccharomyces cerevisiae P39683
-
-
Salmonella enterica subsp. enterica serovar Typhimurium P22253
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O
-
 Mycobacterium tuberculosis beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate
-
 ?
nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O
-
 Mycobacterium tuberculosis H37Rv beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate
-
 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
additional information
-
 thermostability of the enzyme is increased by ATP and 5-phospho-alpha-D-ribose 1-diphosphate Saccharomyces cerevisiae
additional information
-
 thermostability of the enzyme is increased by ATP and 5-phospho-alpha-D-ribose 1-diphosphate Salmonella enterica subsp. enterica serovar Typhimurium

pH Stability

pH Stability pH Stability Maximum Comment Organism
8.3
-
 native enzyme, unstable Salmonella enterica subsp. enterica serovar Typhimurium

Cofactor

Cofactor Comment Organism Structure
ATP 1640fold increase in the product/substrate ratio Salmonella enterica subsp. enterica serovar Typhimurium