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Literature summary for 6.3.4.21 extracted from

  • Kosaka, A.; Spivey, H.O.; Gholson, R.K.
    Yeast nicotinic acid phosphoribosyltransferase. Studies of reaction paths, phosphoenzyme, and Mg2+ effects (1977), Arch. Biochem. Biophys., 179, 334-341.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
5-phospho-alpha-D-ribose 1-diphosphate at high concentrations, when Mg2+ below 0.03 mM Saccharomyces cerevisiae
ATP at high concentrations with Mg2+ below 0.03 mM Saccharomyces cerevisiae
MgADP- non-competitive to Mg-ATP or Mg-diphosphate Saccharomyces cerevisiae
nicotinate mononucleotide competitive to MgATP2-; non-competitive to nicotinate Saccharomyces cerevisiae

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ requirement Saccharomyces cerevisiae
Mg2+ 0.5-15 mM Saccharomyces cerevisiae
phosphate 50 mM, strongly stimulates Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Saccharomyces cerevisiae

Reaction

Reaction Comment Organism Reaction ID
nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate sequential steady state mechanism Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O
-
Saccharomyces cerevisiae beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate
-
?

Synonyms

Synonyms Comment Organism
nicotinate phosphoribosyltransferase
-
-

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Saccharomyces cerevisiae