Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-phospho-alpha-D-ribose 1-diphosphate | at high concentrations, when Mg2+ below 0.03 mM | Saccharomyces cerevisiae | |
ATP | at high concentrations with Mg2+ below 0.03 mM | Saccharomyces cerevisiae | |
MgADP- | non-competitive to Mg-ATP or Mg-diphosphate | Saccharomyces cerevisiae | |
nicotinate mononucleotide | competitive to MgATP2-; non-competitive to nicotinate | Saccharomyces cerevisiae |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | requirement | Saccharomyces cerevisiae | |
Mg2+ | 0.5-15 mM | Saccharomyces cerevisiae | |
phosphate | 50 mM, strongly stimulates | Saccharomyces cerevisiae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Saccharomyces cerevisiae |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate | sequential steady state mechanism | Saccharomyces cerevisiae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O | - |
Saccharomyces cerevisiae | beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
nicotinate phosphoribosyltransferase | - |
- |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Saccharomyces cerevisiae |