Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | no inhibition by 4-hydroxy-nicotinate | Homo sapiens | |
Nicotinate analogues | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.024 | - |
nicotinate | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | requirement | Homo sapiens | |
Mg2+ | synergism with ATP | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood platelet | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | one mol ATP is cleaved per mol product formed | Homo sapiens | ? | - |
? | |
additional information | no ATPase activity in the absence of substrates | Homo sapiens | ? | - |
? | |
nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O | the pyridine N and carboxyl groups are important for interaction with the enzyme | Homo sapiens | beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | 1 mol ATP is hydrolyzed to ADP plus phosphate per mol product formed | Homo sapiens | |
ATP | together with Mg2+ | Homo sapiens |