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Literature summary for 6.3.4.19 extracted from

  • Shapiro, A.B.; Plant, H.; Walsh, J.; Sylvester, M.; Hu, J.; Gao, N.; Livchak, S.; Tentarelli, S.; Thresher, J.
    Discovery of ATP-competitive inhibitors of tRNAIle lysidine synthetase (TilS) by high-throughput screening (2014), J. Biomol. Screen., 19, 1137-1146 .
    View publication on PubMed
Search for more literature for 6.3.4.19

Application

Application Comment Organism
analysis development of a ultrahigh-throughput, fluorescence anisotropy-based assay for the incorporation of lysine into Ile2 tRNA Escherichia coli
analysis development of a ultrahigh-throughput, fluorescence anisotropy-based assay for the incorporation of lysine into Ile2 tRNA Pseudomonas aeruginosa

Cloned(Commentary)

Cloned (Comment) Organism
-
 Escherichia coli
-
 Pseudomonas aeruginosa

Inhibitors

Inhibitors Comment Organism Structure
3-bromo-N-(3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine competitive with respect to ATP Escherichia coli
3-bromo-N-(3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine competitive with respect to ATP Pseudomonas aeruginosa
4-(2-fluoro-5-methoxyanilino)-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one competitive with respect to ATP Escherichia coli
4-(2-fluoro-5-methoxyanilino)-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one competitive with respect to ATP Pseudomonas aeruginosa
N-(3-methoxyphenyl)-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine competitive with respect to ATP Escherichia coli
N-(3-methoxyphenyl)-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine competitive with respect to ATP Pseudomonas aeruginosa

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Pseudomonas aeruginosa
-
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0016
-
 pH 8.5, temperature not specified in the publication Escherichia coli 3-bromo-N-(3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
0.0016
-
 pH 8.5, temperature not specified in the publication Escherichia coli 4-(2-fluoro-5-methoxyanilino)-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one
0.0042
-
 pH 8.5, temperature not specified in the publication Escherichia coli N-(3-methoxyphenyl)-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
0.042
-
 pH 8.5, temperature not specified in the publication Pseudomonas aeruginosa N-(3-methoxyphenyl)-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
0.062
-
 pH 8.5, temperature not specified in the publication Pseudomonas aeruginosa 4-(2-fluoro-5-methoxyanilino)-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one
0.12
-
 pH 8.5, temperature not specified in the publication Pseudomonas aeruginosa 3-bromo-N-(3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine